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Following the huge success of the first edition, which has become THE reference source for everyone working in the field, this long-awaited, completely updated edition features。

Optimizing the compatibility of boronic acids for MCR is an interesting synthetic challenge, as the C─B bond is well known to react with common MCR starting materials and intermediates under mild conditions,。

Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the。

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